Designing a self-healing stent
This project seeks to attach resveratrol, a compound found in red wine, to metal cardiovascular stents. Stents are used in patients with Coronary artery disease, but often fail from improper healing. Resveratrol has been shown to have the potential to improve cardiovascular healing. Our hypothesis is that a stent releasing resveratrol or analogues will improve healing, leading to device Success with less risk to patients. To accomplish this goal, we will (1) optimize the attachment of resveratrol and analogues to metal surfaces, (2) characterize the release of these molecules, and (3) evaluate the response of endothelia cells to the surfaces.