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Mechanisms of protein aggregation in Parkinson’s disease using zebrafish

Our lab studies the mechanisms that regulate neuron development as well as disease. Parkinson's Disease involves the abnormal aggregation of a protein called alpha-synuclein. In collaboration with Dr. Vivek Unni’s lab at Oregon Health & Science University (OHSU), we have established a zebrafish model for studying alpha-synuclein function in the living brain. Because zebrafish are transparent during development, we are able to visualize a fluorescence-tagged form of alpha-synuclein in vivo using confocal microscopy.

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