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Mechanisms of protein aggregation in Parkinson’s disease using zebrafish

Our lab studies the mechanisms that regulate neuron development as well as disease. Parkinson's Disease involves the abnormal aggregation of a protein called alpha-synuclein. In collaboration with Dr. Vivek Unni’s lab at Oregon Health & Science University (OHSU), we have established a zebrafish model for studying alpha-synuclein function in the living brain. Because zebrafish are transparent during development, we are able to visualize a fluorescence-tagged form of alpha-synuclein in vivo using confocal microscopy.

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A Mantra for Hegel? Kaśmiri Śaivism and Hegel on Language.

Kashmiri Shaivism maintains that Shiva is incomprehensible. The Absolute is comprehensible, Hegel claims. Is there something that compels a decision for toward either Shaivism or Hegel? The larger question: Is ultimate truth—be it called Shiva, the Absolute, or the Unified Field Theory—comprehensible?

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The War Beyond the West: Rethinking the Great War in Austria-Hungary and the Balkans

First, how does consideration of Austria-Hungary and the Balkans change our understandings of World War I? These geographic areas have long been overshadowed in a field of scholarship dominated by work on the Western front (Britain, France Germany). Second, how did the home front populations in these areas react and respond to the extraordinary strains of everyday life during Europe’s first “total war”?

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Investigating Forest Recovery in River View Natural Area After Removal of Invasive Plant Species

In fall 2011, the city of Portland purchased 146 acres of forest adjacent to the Lewis & Clark College campus, creating the River View Natural Area (RVNA). At that time, RVNA was heavily invaded by non-native plants. The city removed these species by cutting/herbicide. This action created an opportunity to investigate forest recovery after invasive removal. Will native species return without further management? Or will removal of these species lead to new invasions by non-native plants?

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An Exhibit: Diderot at 300, Making Knowledge Happen in the 18th Century

At the center of the exhibit, the Encyclyopédie's schematic tree of knowledge inspired by Bacon's own, displays the interdisciplinary and collaborative nature of knowledge-making in the 18th-century. Branching out into the faculties of Memory, Reason, and Imagination, human understanding is featured as the subversive key to accessing, critiquing, and creating knowledge through the disciplines ramifying from these faculties - including philosophy, history, and literary creative arts.

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Ribosome biogenesis and export

The long-term goal of this project is to understand how cells make ribosomes. One of the ways in which cancer cells differ from normal cells is their huge rate of ribosome biogenesis, and thus understanding how cells assemble and export ribosomes may provide new therapeutic targets for the specific inhibition of cancer cell growth.

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Surface Chemistry of Gold Nanoparticles in Natural Environments

Gold nanoparticles (Au NPs) are currently the subject of research efforts focused on developing highly sensitive sensors, diagnostic techniques, and targeted drug therapies. As these NPs move from the research lab to large-scale production, they will inevitably be released into the environment. This project sought to explore the eventual fate of these nanoparticles after release into the environment.

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Orego: Artificial Intelligence and the Game of Go

Go (Weiqi), the oldest strategy game in the world, was invented in China thousands of years ago. Its rules are simpler than those of Chess, but its strategies more subtle and profound. Top human Go players, unlike Chess players, can still easily defeat the most powerful computers. The space of possible board configurations is unfathomably vast, many orders of magnitude larger than the number of electrons in the universe. We suspect that human Go strength depends on the ability to decompose the game into local subproblems that are largely, but not quite, independent.

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